Peanuts is one of the most common foods that people are allergic to
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Adults with peanut allergy reduced their risk of reactions by eating a small peanut protein every day as part of a sample. This approach is already approved in the United States for children with the condition.
Peanut allergy occurs when the immune system mistakenly identifies proteins in the vegetable as a threat. It responds by producing several IgE antibodies, which is an important part of the immune responsibility, but exaggerate with allergic reactions. As a result, inflammation rams and causes symptoms such as sweetling, itching and vomiting. In extreme boxes, it can lead to anaphylactic shock, a life -threatening reaction that can affect the breathing of others or their heartbeat.
Until recently, the only solution was to avoid peanuts, but an intervention called oral immunotherapy was approved for children with the allergy in the United States by 2020. This involves educating the immune system to tolerate the allergen by exposing it to gradually include doses of peanut dimensions.
However, it was unclear whether the procedure also worked in adults. “Most of the life of a peanut allergic individual is spent as an adult, but we have had no treat to reduce their underlying reactivity to peanuts,” says Stephen Till at King’s College London. “There are some groups to suspect that adults would be more difficult to desensit than children because your immune system is easier to change when you are younger.”
To fill this Videngap, Till and his colleagues recruited 21 adults with peanut allergy. At the beginning of the study, participants were only able to eat up to an eighth of a peanut on average before having an allergic reaction.
The team got each participant to eat the protein equivalent of a 40. Of a peanut every day for two weeks. This dose was slightly increased every other week for months until they could safely and consistently eat the protein equivalent of four large peanuts every day for a month.
Three participants fell out of the study due to allergic reactions, while three others left due to reasons not associated with the treatment. “This dropout number is acceptable for this kind of treatment,” says Cezmi Akdis at the Swiss Institute of Allergy and Asthma Research.
The remaining 15 participants participated in an allergy test where they ate rising doses of peanut protein under the supervision of the researchers. Everyone except one of them was able to eat equivalent to five peanuts without having an allergic reaction.
In another part of the experiment, team analysis collected blood tests from the participants before and after receiving oral immunotherapy. This dream that intervention caused them to have high levels of IgG antibodies that counteract the effects of IgE antibodies.
“It’s very promising,” says AKDIS. “This approach can mean that adults with peanut allergy can be revived by the anxiety of eating food contaminated with peanuts.
But this was a relatively early trial and greater is reduced to reverse the results and determine how long the protection lasts, he says. “I expect you to have to take daily or ordinary doses of peanuts in the long term to keep tolerance to the allergen,” says AKDIS. “People take pills every day, so I think people affected by peanut allergies may well be fine adhesion of the fate of this method.”
Talk to your doctor before seeking new treatments for medical conditions.
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